Police said the shooting happened in the Cabrini-Green neighborhood's 900-block of North Cambridge Avenue just before 4:30 a.m.
A 20-year-old woman was outside when an unknown offender approached her on foot and fired shots, police said.
The victim, shot in her chest, was transported to Northwestern Hospital, where she was pronounced dead.
No one is in custody and detectives are investigating.
Police did not immediately provide further information about the shooting.
Chicago shootings: Tracking gun violence in 2024, with live updates
INTERACTIVE SAFETY TRACKER Track crime and safety in your neighborhood