ISP responded to the crash in the eastbound lanes of Interstate 290 at Leavitt Street around 10 p.m. That's near the Illinois Medical District.
A vehicle traveled onto the shoulder and struck a curb, causing it to roll over, ISP said.
The passenger in the vehicle was taken to a local hospital, where they were pronounced dead.
The driver was not injured.
The victim's identity was not immediately released.
Authorities did not immediately say what caused the crash.
Further information was not immediately available.