The shooting happened around 3:09 a.m. Friday near 144th and Center Avenue in Harvey, officials said.
A 42-year-old man was shot inside his vehicle, causing him to loss control and crash into two homes, a Harvey spokesperson said.
The driver was shot in the chest. He was later pronounced dead. His identity has not yet been released.
The shooting victim had recently celebrated his birthday, a Harvey spokesperson said.
One family in a home that was hit by the shooting victim's vehicle said no one inside was hurt after the crash.
A homicide investigation is ongoing.
No further information was available.