The crash occurred at about 3:10 a.m. in the 5500-block West Division Street.
Police said two people in a vehicle driving westbound on Division Street when they lost control of their vehicle and hit another vehicle going westbound.
The first car then struck two buildings and damaged them both, police said.
The driver and passenger in the first car then fled the scene and are not in custody, police said. Area Five detectives are investigating.