Police responded to the scene in the southbound lanes of the Bishop Ford at 159th Street at 2:23 a.m.
Police said a driver from a disabled vehicle in the middle lane got out and was attempting to cross active traffic and was struck by a passing vehicle that remained on the scene.
The pedestrian was pronounced dead at the scene, police said. The Cook County Medical Examiner's Office said the victim is a 44-year-old woman.
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The southbound lanes of the Bishop Ford have were closed between 147th and 159th streets before reopening shortly after 8 a.m.