Illinois State Police said the crash happened at about 6:27 a.m. on the southbound lanes of Arsenal Road.
Chopper 7 was over the scene at about 7:30 a.m.
ISP said three people were taken to area hospitals.
One person died, ISP said.
The southbound lanes of the Frontage Road were shut down and reopened at approximately 11:00 a.m.
CHICAGO TRAFFIC See LIVE drive times