The crash happened at about 3:08 a.m. on the southbound lanes of I-55 at the Tri-State Tollway.
ISP confirmed the crash was deadly but did not release more information about the victims.
As of 7:15 a.m. southbound lanes of I-55 were shut down and the I-294 northbound ramp to southbound I-55 was also closed.
Traffic was being diverted to La Grange Road.
All lanes reopened on by 9:20 a.m.
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