Chopper 7 was over the scene at about 6:20 a.m. at Dixie Highway near 162nd Street in Markham.
Both lanes were shut downas of 6:30 a.m.
It is unknown how many people were injured in the crash, or what led to it.
A large first responder presence was at the scene treating some of the victims, video showed.
Police have yet to release information on the south suburban crash.