The incident occurred at about 6:06 a.m. in the inbound lanes of I-290 at Independence Boulevard.
Police said the driver of a box truck reported someone from a passing vehicle fired shots at their vehicle.
The driver is being treated for injuries, police said.
All inbound lanes were closed at Independence Boulevard, Illinois State Police said. Shortly after 7:30 a.m., police then began reopening lanes to traffic.
Further details were not immediately available.