ISP said two cars were involved in the crash on westbound I-88 at about 4 a.m. in Aurora.
The alleged wrong-way driver was heading eastbound in the westbound lanes when they crashed head on.
Three people died in the crash.
Their identities were not immediately released.
At 7:47 a.m. I-88 was still shut down from Orchard Road to Route 47, ISP said.
Police reported serious injuries, however, it was unclear how many people were injured.
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