Chopper 7 was over the scene just after 7 a.m. on the northbound lanes of I-55 at La Grange Road.
Illinois State Police said the crash happened at 4:25 a.m.
A semi's load struck the overpass bridge, ISP said.
Video from Chopper 7 shows a type of spill on the expressway.
It was not immediately clear what spilled on the expressway, however Hazmat crews were called.
As of 11:30 a.m. traffic was still only able to get by using the shoulder.
One person was taken to an area hospital with injuries.
No other information was available.
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