The crash happened just before 8 a.m. near East Monroe and South Columbus Drive in the Loop, police said.
A driver, a 19-year-old man, was traveling eastbound on Monroe when he allegedly disobeyed a solid red light, CPD said. He then struck a vehicle traveling northbound on Columbus.
The driver of the other vehicle, 47-year-old man, was taken to a local hospital in good condition, police said.
The 19-year-old driver was also taken to a hospital after he had a cut to his forehead due to the crash.
Citations are pending as Chicago police continue to investigate.
No further information was immediately available.