The crash happened Friday afternoon at Pershing Road and King Drive in Bronzeville.
Chopper 7 was over the scene, where a crash appeared to involve a CTA bus and at least one passenger vehicle.
Chicago fire officials said 15 people were taken to hospitals after the crash. One person was in critical condition and another was in serious condition. The 13 other people were in good condition.
Five more people at the scene for checked out and were not taken to a hospital, CFD said.
The cause of the crash was not yet known. It was unclear how many injured people may have been on the CTA bus or in a passenger vehicle.
This is a developing story. Check back for updates.