The crash happened at about 9:47 p.m. on Halsted Street near 110th Street in Morgan Park, police said.
A 26-year-old woman was driving an SUV southbound on Halsted when it crashed into a blue car heading eastbound, Chicago police said.
The driver of the blue car was an 81-year-old woman, police said. She died at an area hospital due to body trauma, police said.
The 26-year-old driver was taken to the hospital, but is expected to be OK.
Two other women, 46 and 51, were also in the blue car; both were treated for injuries related to the crash. Both are also expected to be OK.
Chicago police have not announced any charges or citations related to the crash.