The male driver of a white Honda sedan was traveling north in the 8100-block of Stony Island Avenue just after 12:45 a.m. when he lost control and struck a tree in Avalon Park, CPD said.
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The male driver was pronounced dead on the scene, and has not been identified.
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A female passenger was also pronounced deceased on the scene. CPD did not immediately provide her identity or the ages of either victim.
The Major Accidents Unit is investigating the incident.
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Emergency crews were no longer on the scene as of about 5:20 a.m.