The crash happened at about 11:50 p.m. in the 4400-Block of S. Pulaski Road, according to police.
A man was speeding northbound on Pulaski in a white Jeep Cherokee, when police said he struck a 67 -year-old male in a Honda Pilot who was entering traffic onto Pulaski.
The driver of the Cherokee lost control and struck a tree, then a fence.
The Cherokee caught on fire, and the driver died at the scene.
No other injuries were reported.
Chicago PD Area One detectives are investigating.