The crash happened at about 3:50 a.m. in the 3800-block of West Lake Street, according to police.
A 20-year-old was driving eastbound in a blue Ford sedan with three passengers. Police said he allegedly disregarded a traffic signal and crashed into a red Chevy sedan that was heading southbound.
One of the passengers of the blue sedan died at the hospital from his injuries. Police said he was a 22-year-old man.
The three other 20-year-old men in the blue car were taken to area hospitals. The extent of their injuries was not released.
The woman,37, driving the Chevy and her 35-year-old passenger refused medical services.
Chicago police said citations are pending.