The crash happened around 4:40 p.m. in the 3200 block South Halsted Street in Bridgeport, Chicago police said.
A 35-year-old bicyclist was hit by a vehicle in traffic. The man was taken to a hospital where he was later pronounced dead, police said.
His name has not been released.
CPD's Major Accidents Investigation Unit is investigating the crash.
No further information was immediately available.