The crash happened at about 2:19 a.m. in the 400-block of Jefferson Street in the West Loop neighborhood, police said.
When CPD officers arrived, they found that a white car had crashed into the support column of the I-290 Eisenhower Expressway and was on fire.
Chicago firefighters extinguished the fire.
Two people were found dead inside the vehicle, Chicago police said.
No other information was available.