The incident took place at about 11:35 p.m. in the 2500-block of South Christiana Avenue.
Police said officers arrived at the scene and found a woman was found with multiple puncture wounds and pronounced dead at the scene.
A 59-year-old man was found with multiple stab wounds and transported to Mt. Sinai Hospital, where he was listed in serious condition, police said.
A weapon was recovered from the scene and Area Four detectives are investigating.
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