The stabbing happened at about 11:43 p.m. on Saturday in the 4400 block of W. 55th Street, police said.
Police said three men were in a physical altercation with two unknown men.
CPD said someone in the group then pulled out a sharp object and began to stab three victims.
A 19-year-old man was stabbed in the neck and was taken to Mt Sinai Hospital and was listed in serious condition.
A 21-year-old man was stabbed multiple times to the body and was taken to Mt Sinai Hospital in serious condition.
A 41-year-old man was stabbed in the neck and was taken to Christ Hospital. He was listed in "fair condition."
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Police said nobody is in custody.