The shooting happened at about 8:15 p.m. at a hotel at Grand Avenue and Orleans Street in the River North neighborhood, police said.
The first victim, a 29-year-old woman, was found shot in the neck inside the hotel lobby by police.
She was taken to the hospital and is expected to be okay.
A 32-year-old woman was later found inside a hotel room with a gunshot wound to the shoulder. She was taken to Northwestern Hospital where she died.
The suspect allegedly drove off in a tan colored SUV which last seen heading eastbound. Nobody is in custody.
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