The incident happened at a residential complex in the 7800-block of East End Avenue around 1:35 a.m., police said.
A 20-year-old man was victim was inside the home when he was attacked by a man.
The suspect allegedly pulled out a sharp object, stabbed the man, then ran away.
The 20-year-old was taken to the hospital with multiple cuts and stab wounds. He died at the hospital, Chicago police said.
No one in custody. CPD Area Two detectives are conducting a homicide investigation.
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