The man, 31, was shot in his back around 1:20 p.m. in the 800 block of North LeClaire Avenue in the city's South Austin neighborhood, Chicago police said. Paramedics took him to Stroger Hospital, where he was pronounced dead.
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At least three other people were murdered in Chicago on Friday.
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About an hour earlier, a 61-year-old man was shot to death in the South Shore. At least two gunman came up to him on a sidewalk in the 7700 block of South Saginaw Avenue and opened fire. He died of a gunshot wound to his chest at South Shore Hospital.
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Chicago police are also investigating after two men were found stabbed to death in the street, on the South Side.
The victims were found shortly before 7 a.m. in the 7500 block of South Sangamon Street in the city's Gresham neighborhood. Police initially found one man stabbed. After he was taken to a hospital and pronounced dead, officers canvassing the scene found another man dead of a stab wound to his neck.
Police reported no arrests in any of the murders.
The Sun-Times Media Report contributed to this post.