Chicago police said the crime happened at 3:12 a.m. in the 2400-block of North Clark Street.
Store owners shared surveillance video showing as the burglars broke the front door window to enter.
One suspect was seen using a sledge hammer and break a video gaming machine.
Video shows brazen burglary at Chicago's Lincoln Park Food & Liquor theft
The store manager told ABC7 this was the second time in less than two months that the store was burglarized.
Chicago police said the suspects drove off in a white car and fled southbound.
No other information was available.
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On Wednesday a "The Other Side Bar" was also broken into on the same block.
Chicago police said it happened at 5:28 a.m. In that case, suspects also fled in a white car.