The fire happened in the 10100-block of Indianapolis Avenue around 11:58 p.m. on Saturday, CPD said.
Chicago firefighters entered the residence and escorted two adults and two children from the smoke-filled home.
Two adults had non-life-threatening injuries and were taken to the hospital, they were listed in good condition.
Two boys, aged 2 and 8, were taken to a children's hospital as a precaution and are listed in good condition.
The cause of the fire is still under investigation.
No other information was immediately available.