The fire happened before 6:30 a.m. at a business at Irving Park Road and Major Avenue.
The firefighter response caused multiple roads in the area to be closed and multiple busses to be rerouted.
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Chopper 7 was over the scene at about 6:45 a.m. showing as crews were on the roof of a business working to put out flames.
It is unknown which business the fire erupted from. The cause of the blaze is unknown.
Chicago firefighters have not released any information.