The fire broke out at about 5 a.m. in an apartment building in the 4500-block of South Laflin Street.
Chopper7 flew above the scene as the fire produced heavy smoke and flames. The roof of one building appeared to have collapsed and a neighboring building appeared to also be damaged.
CFD battles extra-alarm fire in Back of the Yards
Fire officials said two civilians and two firefighters suffered minor injuries. Fourteen people have been displaced by the fire.
The cause of the fire is under investigation.