The house fire appeared to be in the 4800 block of South Ada Street in Back of the Yards.
Video posted to social media showed the fire.
Chicago firefighters battling house fire on South Side: VIDEO
Chicago Fire Department firefighters could be seen battling the house fire.
There was no word yet on if there were any injuries.
ABC7 has reached out to CFD for more information.
This is a breaking news story. Check back with ABC7 for updates.