Chicago police and fire crews responded just before 6:30 a.m. to the 7700-block of Damen Avenue in Chicago's Gresham neighborhood for a reported fire.
The man was taken to Stroger Hospital in serious condition amid the fire, police said.
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No other injuries were reported.
The incident is currently classified as non-criminal - accidental, CPD said.
Chopper 7 captured firefighters using ladders to get access to the second floor of the house.