Police say J'Adore Frazier was last seen on Friday, June 6.
They say the boy's father, Christopher Upshaw, took him from his grandparents' home around the Brainerd neighborhood's 9000-block of South Aberdeen Street.
The two may be traveling in a beige Cadillac sedan. Frazier was last seen wearing a beige sweat suit and black sneakers.
Police urged anyone with information on Frazier's whereabouts to contact Area Two detectives at 312-747-8274 or call 911.