The shooting happened around 10:40 a.m. in the 2500 block of West 46th Street in Brighton Park, Chicago police said.
A 16-year-old boy and a 40-year-old man were on the street when an offender exited a vehicle and fired shots at them, police said.
The teen was shot in the head and chest. He was taken to a hospital and later pronounced dead.
The victim was later identified as 16-year-old Santino Rojas, who lived near the shooting scene, the Cook County Medical Examiner said.
The man was taken to Mount Sinai hospital after being shot in the chest and leg. He was initially listed in grave condition.
No further information about the shooting was immediately available.
Chicago police continue to investigate.
INTERACTIVE SAFETY TRACKER Track crime and safety in your neighborhood