The shooting happened at about 1:59 a.m. in the 1300 block of South Loomis Street in University Village.
Police said two victims were in a car when someone in a vehicle started to shoot at them.
A 25-year-old woman was shot in the head and the right leg. She was rushed to the hospital in serious condition.
A 25-year-old man was also rushed to the hospital in serious condition after being shot in the chest.
No one in custody.
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