The shooting occurred at about 3 a.m. in the 9100-block of South Harper Avenue.
The victims were standing on the sidewalk when police said someone in a red sedan fired shots, wounded the four victims.
A 44-year-old man was transported to the University of Chicago Medical Center in fair condition, police said.
A 37-year-old man walked into Trinity Hospital in fair condition with a gunshot wound to the arm, police said.
A 33-year-old woman walked into Trinity Hospital with a gunshot wound to the neck and is listed in critical condition, police said.
A 30-year-old man walked into Trinity Hospital with a gunshot wound to the leg and is in fair condition, police said.
No one is in custody. Area Two detectives are investigating the circumstances surrounding the shooting.
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