The shooting took place at about 8:50 p.m. in the 5600-block of South Maplewood Avenue.
Police said a 17-year-old boy and a 14-year-old girl were talking when two unidentified male suspects shot at them and fled the scene.
The boy was shot multiple times and transported to the University of Chicago Medical Center, where he was pronounced dead, police said.
The girl suffered graze wounds to the leg and head and transported to Comer Children's Hospital, where she was listed in good condition, police said.
Area One detectives are investigating. No one is in custody, police said.
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