Police said officers responded to the shooting in the Chicago Lawn neighborhood's 3200-block of West 62nd Street just before 3 a.m.
A 30-year-old man was standing outside when male suspects pulled up in a silver sedan, and a passenger took out a gun and fired shots, police said.
Police said the victim, shot in the body multiple times, was pronounced dead on the scene.
Area One detectives are investigating.
Further information was not immediately available.
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