Police said the shooting happened in Roseland in the 11500-block of South LaSalle Street just before 1 a.m.
Officers responded to a call about a person shot and found a 38-year-old man on the ground. He had suffered a gunshot wound to his head.
The victim was pronounced dead on the scene, police said.
A witness told officers that a red two-door vehicle fled the scene.
No one is in custody and Area Two detectives are investigating.
Police did not immediately provide further information about the shooting.
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