Police said the shooting happened in the Chicago Lawn neighborhood near West 63rd Street and South Francisco Avenue just before 3 p.m.
A 28-year-old woman was sitting inside of a vehicle when at least one person, identified only as male, approached her and fired shots, police said.
The victim, shot in her back, was transported to Christ Hospital, where she was pronounced dead.
There is no one in custody and Area One detectives are investigating.
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