The shooting took place at about 9:45 p.m. in the 1500-block of East 95th Street.
Police said the woman was traveling in a vehicle when someone traveling in a silver SUV shot at her.
The woman was wounded in the head and transported to the University of Chicago Medical Center in critical condition, police said.
Video from the scene showed a black Jeep blocked by crime tape as officers investigated the scene.
The shooting happened near a shopping center with several stores, restaurants and a gas station that would've been open at the time.
Police said no one is in custody. Area Two detectives are investigating.
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