The shootout happened around in the 1400 block of East 65th Place in Woodlawn, Chicago police said.
Two male offenders with a firearm entered a home and battered a 26-year-old man, police said. The suspect then exchanged gunfire with a 48-year-old woman at the home.
The suspects fled the scene in a dark-colored vehicle westbound on 65th Place, CPD said.
The man who was battered suffered a bruise to his head. No other injuries were reported.
No arrests have been made as Chicago police continue to investigate.
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