Police said the three-vehicle crash occurred at about 2:38 a.m. in the outbound lanes between the junction and Lawrence.
Two people were transported to area hospitals with life-threatening injuries, police said.
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All lanes were shut down just south of the split with the Edens Expressway, with all traffic being diverted to the outbound Edens expressway. Shortly after 8:30 a.m., lanes were reopened.