The crash happened at about 8:51 a.m. on the northbound lanes of the Bishop Ford Expressway at 115th Street.
Illinois State Police said a semi crashed into a car for unknown reasons.
One adult and three children were seriously injured. All were rushed to local hospitals.
ISP said all northbound lanes were shut down.
At about 9:50 a.m. Chopper 7 was over I-94 and all lanes were back open.
No other information was available.
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