The crash happened at about 7:11 a.m. on the outbound lanes of I-94 Edens Expressway just north of Winnetka Road, ISP said.
The driver crashed into a concrete wall and was rushed to the hospital where they later died.
No other vehicles were involved.
ISP did not release any further information.
Crews were blocking the left lane of traffic as the investigation continued.
CHICAGO TRAFFIC | See LIVE drive times