The crash happened at about 9:09 p.m. at the intersection of 35th and Leavitt Street, according to Chicago police.
The ambulance was traveling westbound with lights and sirens on 35th Street when it crashed with a red SUV travelling northbound on Leavitt.
Two people inside the SUV were taken to the hospital. They are expected to be okay.
Two paramedics were also taken to the hospital. Their conditions have not been released.
Video shows the SUV flipped over after the crash.
No other information was available.
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