All southbound lanes of the Kennedy were closed at Division Street about 2:15 a.m., after the crash occurred, police said. Soggy packages could be seen on the expressway, as rain covered the Chicago area throughout the morning.
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The crash is expected to affect traffic for several hours, while crews work to clean up the scene, police said. As a result, the reversible lanes on the Kennedy Expressway are now open to southbound traffic to ease congestion.
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The driver of the FedEx truck suffered minor injuries, police said.
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The cause of the crash is still under investigation, but it appears the driver was traveling too fast for wet conditions, police said.
Traffic was still affected later Wednesday morning.