The crash happened at about 2:12 a.m. in the 7700-block of S. Vincennes Avenue in the Gresham neighborhood.
A white Chrysler 300 was heading southbound when it crashed into a pole, according to police.
Five people were inside the vehicle.
A man riding in the backseat died at the scene. He has not been identified by police.
The driver, a 19-year-old man, broke his femur and hip. He was taken to the hospital in serious condition.
An 18-year-old male passenger was taken to the hospital with multiple cuts; he is expected to be okay.
A 22-year-old man was also taken to a nearby hospital with unknown injuries; he is also expected to be okay.
A fifth male passenger had a broken femur and taken to the hospital in serious condition.
No other vehicles were involved.
Chicago police said charges were pending.