The crash occurred at about 6:47 a.m. in the 2200-block of South Lake Shore Drive.
Police said a Ford sedan was struck by an unknown vehicle, and the Ford then lost control and hit a Lexus SUV.
The 31-year-old woman driving the Ford, 70-year-old man driving the Lexus and his 71-year-old passenger were all transported to The University of Chicago Medical Center with non-life threatening injuries, police said.
The driver of the vehicle that hit the Ford fled the scene, police said.
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At one point, all northbound lanes were blocked as police investigated.