The crash happened on I-57 south of 127th Street just south of Calumet Park.
Chopper 7 was over the scene around 6 a.m. Two vehicles were involved in the crash.
Video shows as one of the cars rolled over onto the second car.
So far, minor injuries have been reported.
CHICAGO TRAFFIC | See LIVE drive times
It is unknown how long the expressway will be closed due to the crash.
At about 6:20 a.m. police opened up the shoulder to allow some traffic to drive through.
Southbound traffic is being diverted off I-57 at 127th Street.
Delays were also reported on the northbound lanes of I-57.
All lanes were back open by 9 a.m.
Illinois State Police did not release more information.