The crash happened on the eastbound lanes of Irving Park Road between Keeler Avenue and the Kennedy.
Chopper 7 over scene around 6:30 a.m., showing the semi on its side.
It is unknown if there are reports of serious injuries.
CTA rerouted the eastbound #80 Irving Park buses due to the crash.
Although lanes eastbound lanes Irving Park Road were closed, traffic was allowed to slowly go around the crash.
It is unclear how long it will take to clean up the site.
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