The crash happened at about 4:47 a.m. on I-94 near Dempster Street, according to ISP.
Police said at least six vehicles were involved in the crash.
A pedestrian was also struck by a vehicle at the scene, police said.
It was not immediately clear if the pedestrian was a passenger in one of the vehicles.
The pedestrian and several passengers were taken to local hospitals with injuries.
The extent of their injuries was not immediately known.
Illinois State Police confirmed all northbound lanes of I-94 reopened by 11:22 a.m.
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